Cyclophosphamide Induces Hepatorenal Toxicity and Attenuation by 5-fluorouracil in Male Albino Rats

Background: Cyclophosphamide (CPA) induces acute inflammation of the urinary bladder, renal damage, and liver thereby limiting its therapeutic use. Objectives: The present study aimed to evaluate hepatorenal toxicity induced by cyclophosphamide amelioration 5-fluorouracil in male albino rats. Materials Methods: Twenty-eight adult rats were grouped randomly into four groups (n=5 for each group). Group I (control): Rats injected with saline intraperitoneally at a dose 1.0 ml/kg b.w. 14 days. II (CPA): 10 mg/kg day through i.p. III Fluorouracil (5-FU): 5-Fluorouracil was given IV (CPA+5-FU): CPA followed 5-FU per (day day) At end experimental period, anesthetized using light ether. Blood samples taken prepared biochemical measurements. Results: Serum total protein, albumin, globulin concentration significantly reduced animal that received cyclophosphamide. combination changes compared treated group. A significant increase LDH serum found CPA, 5-FU, their combination-treated animals. mean values chemotherapy above treatment. Administration resulted AST, ALT, ALP, bilirubin control. Co-treatment attenuated when – Compared controls, urea creatinine levels increased CPA-treated rats, while uric acid combination. produced restored 5-FU. Conclusion: It could be concluded treatment mammals is associated production free radicals lead hazardous alterations parameters. However, produce most cases these changes, it may considered as potentially useful candidate combat oxidative stress-mediated non-target organ injury even if not complete protection. Future work should consider combined regimens, two or more mechanisms action chemotherapeutic drugs powerful than one mechanism. Toxicological studies must performed before application. Further research required on toxicological impacts pollutants mixtures.